COMPOSITION
Closantel (sf. Sodium dihydrate)…. ……………… ................... …………………. ..… .5.00 g
Albendazole ………………………………………………………… ..................… …………………. 3.80 g
Excipient qs ……… .. ………………………………………… ............. ... …………………… ..… 100 ml
PHARMACEUTICAL PROPERTIES
Albendazole is an anthelmintic from the benzimidazole family with great activity against gastrointestinal and pulmonary nematodes and on the tænia. Like other benzimidazoles, Albendazole works by inhibiting the polymerization of microtubilin, causing cell disorganization and death of the parasite by starvation. Albendazole is also active on adult flukes (10 weeks), but inactive on oestras. So the Closantel is active against oesters and immature moats. Thus, the association of these two major anthelmintics forms a broad-spectrum product, active both on the digestive and respiratory strongles, on the moat and on the oestras. Note that Closantel is also endowed with excellent activity on hematophagous nematodes. From a pharmacological point of view, Albendazole is metabolized in the body into several metabolites, of which Albendazole sulfoxide is endowed with a high anthelmintic activity similar to that of the parent product. While Closantel undergoes a very slow metabolism which increases its persistence in the body.
TARGET SPECIES
Cattle, sheep, goats.
INDICATIONS
Treatment of internal parasitic diseases: Gastrointestinal and pulmonary nematodoses, Tapeworm, Fascioliasis (adults and immature) and Oestrosis (ie all larval stages).
ADMINISTRATION AND DOSAGE
Oral use at a single dose of 10 mg Closantel / kg and 5 mg of Albendazole / kg bodyweight, i.e. 2.0 ml suspension / 10 kg bodyweight.
SIDE EFFECTS
If the general conditions of use are respected, no undesirable effects are observed after treatment with Albendazole and Closantel.
PRECAUTIONS FOR USE
Respect the dose in females at the beginning of gestation. Shake well before use. Destroy the container after use.
WITHDRAWAL PERIOD
Meat and offal: 28 days.
PRESENTATION
100ml bottles. 250 ml, 500 ml, 1 L, 2 L and 5 liters.